We develop single-cell genomics, genome engineering, and computational tools to characterize the natural variation in gene expression, its genetic basis, and its effects on disease susceptibility. We are particularly interested in the immune system and the role it plays in infectious disease, autoimmunity, neurodegeneration and cancer.
We have developed new approaches to profile many cells fro many individuals enabling studying the effects of the single unit of inheritance on the single unit of life.
We are developing new tools to precisely edit primary human immune cells in order to systematically study the effects of genetic perturbations.
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